Ezetimibe on Top of Statins in High Cardiovascular Risk Patients with Hypercholesterolemia; OSLER: Open-Label Study of Long-Term Evaluation Against LDL-C Trial; LAPLACE: LDL-C Assessment with PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy; GAUSS: Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects; SPIRE: Studies of PCSK9 Inhibition and the Reduction of Vascular Events. The gene discussed is PCSK9; the disease is familial hypercholesterolemia.