PPARA and renal fibrosis: Mir-181a-5p has been found to downregulate lipid metabolism regulator PPARα [41] and is in silico predicted to downregulate MAT2A, TIMP3, and LGSF11 [42]; miR-451 downregulates YWHAZ and CAB39, which could be implicated in renal fibrosis and mesangial hypertrophy [40].