Ligustrazine can improve inflammation and fibrosis in lung tissue of ALIrats, inhibit PI3K/AKT/mTOR pathway activation, reduce p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR ratios, and reduce LPS-induced ALI[68]. The gene discussed is AKT1; the disease is acute respiratory distress syndrome.