9α-hydroxymatrine, lamprolobine, adenine, matrine, sophoranol, sophoridine, and isomatrine have a degree over 50, indicating that the active compounds of CKI play a role in the treatment of breast cancer by regulating multiple targets, which conforms to the TCM characteristics of multicomponent, multitarget, and multidisease (Supplementary Table 1). The gene discussed is CHKA; the disease is breast cancer.