9α-hydroxymatrine, lamprolobine, adenine, matrine, sophoranol, sophoridine, and isomatrine have a degree over 50, indicating that the active compounds of CKI play a role in the treatment of breast cancer by regulating multiple targets, which conforms to the TCM characteristics of multicomponent, multitarget, and multidisease (Supplementary Table 1). This evidence concerns the gene CHKA and breast carcinoma.