PDE4D and Alzheimer disease: In regard to the group differences for the subjects with the PDE4D variants, significant reductions of Eg values were found in the AD group versus the MCI group (p < 0.05, Bonferroni corrected); the Eloc values were significantly higher in the MCI group than in the NC group (p < 0.05, Bonferroni corrected); Lp values were significantly increased in the AD group compared with the MCI group (p < 0.05, Bonferroni corrected); and the Cp values were obviously enhanced in the MCI group compared with the NC group (p < 0.05, Bonferroni corrected).