APOE and Alzheimer disease: Recent genome-wide association studies (GWAS) on neuroimaging phenotypes have identified several genes and their variants associated with AD, such as APOE, TAU, TOMM40, ABCA7, CLU, CR1, CD33, CD2AP, EPHA1, BIN1, PICALM, MS4A (Bertram et al., 2008; Denise et al., 2009; Jean-Charles et al., 2009; Potkin et al., 2009; Hollingworth et al., 2011; Naj et al., 2011; Bettens et al., 2013; Lambert et al., 2013), and other novel genes, such as ANTXR2, OR5L1, IGF1, ZDHHC12, ENDOG and JAK1 (Elsheikh et al., 2020).