ITIH5 (inter-α-trypsin inhibitor heavy chain 5) has been identified as a novel prognostic marker for breast cancer, mediated by promoter hypermethylation (Veeck et al., 2008), and is a novel candidate tumor suppressor gene in colon cancer (Kloten et al., 2014). The gene discussed is ITIH5; the disease is malignant colon neoplasm.