TYMP and mitochondrial neurogastrointestinal encephalomyopathy: Loss of function changes in TYMP, the gene ending TP, have been associated with a peculiar clinical presentation known as mitochondrial neurogastrointestinal encephalomyopathy (MNGIE, MIM 603041) featuring the following clinical hallmarks: extraocular muscle weakness, gastrointestinal (GI) dysmotility, cachexia, sensorimotor peripheral neuropathy, and leukoencephalopathy (Nishino et al., 1999).