EGR1 and hepatocellular carcinoma: For the turquoise module, we built a genome network which was mapped by three pathways: “Cell adhesion molecules (CAMs),” “ECM-receptor interaction,” and “TGF-beta signaling pathway.” EGR1 (the transcription factor without significant protein-altering mutations) and SOX17 (the transcription factor with significant protein-altering mutations) were selected as the molecules regulating the oncogenesis of HCC (Figure 7A).