A significant increase in SGK1 mRNA was also observed, by means of next-generation RNA sequencing and pathway analysis, in the periaqueductal gray (PAG) of two mouse models of neuropathic pain [spared nerve injury (SNI)] and depression [chronic unpredictable stress (CUS)], revealing that SGK1 expression may indeed link, at a molecular level, pain and chronic stress (Descalzi et al., 2017). The gene discussed is SGK1; the disease is depressive symptom measurement.