The inflammation resulting from physical stress has shown, at least in rats, to be associated with depression in presence of elevated levels of SGK1, both in blood and in hippocampal and amygdala neurons, within the framework of glucocorticoid-dependent depressive effects (Anacker et al., 2013b; Girgenti and Duman, 2018). This evidence concerns the gene SGK1 and depressive symptom measurement.