Interestingly, several SGK1 polymorphic variants are associated with type 2 diabetes, obesity, and increased blood pressure in Caucasian and African populations (Schwab et al., 2008), whereas a strong link between heart disease and depression, both of which are closely related to lifetime stress exposure, has been verified in Chinese Han patients (Han et al., 2019). This evidence concerns the gene SGK1 and depressive disorder.