SGK1 and major depressive disorder: All these studies highlighted that the antidepressant effects of antioxidative compounds are related to the normalization of the “stress protein” SGK1 level in parallel with the restoration of neurogenesis (Figure 1); for this purpose, advanced investigations are needed to fully understand the mechanism of actions including neuroprotection, biotransformation of their metabolites in the body, and potential interactions with molecular target involved in the depression.