Interestingly, a recent paper showed that SGK3, an isoform highly expressed in the brain sharing 80% amino acid sequence identity with SGK1 in the catalytic domain (Kobayashi et al., 1999), induced SGK3-mediated autophagic cell death (ACD), but no apoptosis of hippocampal neural stem cells (NSCs), thereby determining decline of adult hippocampal neurogenesis and cognitive deficits (Jung et al., 2019). This evidence concerns the gene SGK3 and Cognitive impairment.