In details, in rat models of depression induced by unpredictable chronic mild stress (UCMS) or early life stress, a significant increase of the hippocampal SGK1 mRNA level was observed, together with a reduction in Hedgehog signaling, as expected (Anacker et al., 2013b; Bockmühl et al., 2015). This evidence concerns the gene SGK1 and major depressive disorder.