For the identified five top hub genes, HCC patients with high expressions of COL1A2, IGF1, and LPA as well as low expression of SPP1 were found to be associated with the improved DFS (p = 0.0017, p = 0.0021, p = 0.0058, and p = 7e–04, respectively) (Figure 7). This evidence concerns the gene SPP1 and hepatocellular carcinoma.