For example, Non-MLL rearranged AML and chronic lymphocytic leukemia exhibit similar incidence rates of SETD2 mutations (6 and 7%, respectively), and a lower incidence (3%) has been reported in chronic lymphocytic leukemia (Masetti et al., 2016; Parker et al., 2016). This evidence concerns the gene KMT2A and B-cell chronic lymphocytic leukemia.