A total of 110 DEGs were obtained, with nine hub genes related to PAH (PLK4, CENPU, KIF20B, SMC2, ASPM, FANCI, KIF18A, SPDL1, and MIS18BP1), of which PLK4 and SMC2 were particularly significant. The gene discussed is KIF20B; the disease is pulmonary arterial hypertension.