A total of 110 DEGs were obtained, with nine hub genes related to PAH (PLK4, CENPU, KIF20B, SMC2, ASPM, FANCI, KIF18A, SPDL1, and MIS18BP1), of which PLK4 and SMC2 were particularly significant. The gene discussed is MIS18BP1; the disease is pulmonary arterial hypertension.