However, all of these effects were significantly reduced in the EHC group, along with increased expression of the anti-inflammatory genes IL10 and MRC1. In the CNS, LPS binds to the TLR4 receptor and this activation is associated with neurodegenerative diseases (Xiang et al., 2015) and major depressive disorder (MDD). This evidence concerns the gene MRC1 and neurodegenerative disease.