VEGFA and ischemic cardiomyopathy: For ischemic cardiomyopathy, circRNA circFndc3b was found to be significantly downregulated in cardiac tissues of ischemic cardiomyopathy patients, and overexpression of circRNA circFndc3b in cardiac endothelial cells increases vascular endothelial growth factor-A expression and enhances their angiogenic activity and reduces cardiomyocytes and endothelial cell apoptosis (Garikipati et al., 2019).