Based on the high level expression of H19 in early passage cells and its close correlation with the Wnt signaling pathway, we used lentiviral transduction to overexpress H19 in DP cells and assessed viability and HF inducibility, as well as investigated the underlying regulatory mechanisms involving Wnt/β-catenin, to determine the role of H19 in DP cell-induced HF induction in this study. Here, H19 is linked to hydrops fetalis.