Gupta et al. (2010) found that dysregulated HOTAIR increased cancer invasiveness and metastasis through dependence on PRC2, and lncRNA HOXD-AS1 regulated the Rho GTPase activating protein 11A (ARHGAP11A), which resulted in induced metastasis (Lu et al., 2017). In recent years, some lncRNAs have been found to be biomarkers of predicting BRCA patient outcomes, such as lncRNA BCYRN1 (Booy et al., 2017) and HOTAIR (Zhang et al., 2013a), which has attracted increasing attention. Here, HOTAIR is linked to cancer.