Upregulation of MICA on melanoma and colorectal cancer cell lines by treatment with HDACi FR901228 or butyrate, was significantly inhibited by HC treatment (Figure 7H), resulting in reduced binding of NKG2Dfc soluble receptor, as shown in FM78, FM86, and SK-MEL28 (Figure 7I). The gene discussed is MICA; the disease is colorectal cancer.