IFITM3 and viral infectious disease: It has been recently demonstrated that viral infections (e.g., influenza and dengue viruses) upregulated the expression of IFITM3 on platelets and megakaryoctyes, eliciting rapid antiviral immunity, and that megakaryocytes were capable of limiting viral infections in both megakaryocytes and hematopoietic stem cells via secretion of type I interferons (79).