We found that both APP−/− and APP+/+ mESC-TEP-transplanted 3XTg-AD mice had a reduced cerebral Aβ plaque load in the hippocampus, specifically in the dentate gyrus (DG) and in the cerebral cortex (layer V) (Figures 3A–C), areas showing robust Aβ-plaque pathology in AD mice. Here, APP is linked to Alzheimer disease.