In summary, we have demonstrated that transplantation of APP+/+ or APP−/− mESC-TEPs into AD mice attenuates AD pathology, which is associated with enhanced systemic IFNγ-producing T cells and CP gateway activity with increased expression levels of leukocyte homing and trafficking molecules, as well as increased number of macrophages in the CNS. The gene discussed is CP; the disease is Alzheimer disease.