Compared with APP+/+ mESC-TEP-transplanted mice, the percentage of IFNγ-producing CD4 T cells in APP−/− mESC-TEP-transplanted mice showed a larger increase, which is probably due to enhanced anti-Aβ autoimmunity in APP−/− mESC-TEP-transplanted AD mice. This evidence concerns the gene CD4 and Alzheimer disease.