PTK2 and neoplasm: Interestingly, BC can remain dormant and clinically undetectable before late recurrence decades later, and it has been reported that inflammation induced by stimuli such as lipopolysaccharide or smoking triggers neutrophils to accumulate and NET formation, which can cause tumor recurrence by activating the integrin and FAK/ERK/MLCK/YAP signaling pathways to awaken dormant tumor cells (139).