Currently, CARs that target human epidermal growth factor 2 (HER2) and epidermal growth factor receptor variant III (EGFRvIII) against glioblastoma, GD2 disialoganglioside against neuroblastoma, and mesothelin (MSLN) against mesothelioma, are being evaluated in clinical trials (4). The gene discussed is MSLN; the disease is mesothelioma.