Dupilumab, a monoclonal antibody that targets IL-4Rα, inhibiting IL-4/IL-13 signaling, has demonstrated both clinical efficacy and modulation of Th2 cytokines (e.g., IL-13, CCL17, CCL18, CCL26) and other inflammatory mediators in skin from AD patients (1, 12–14). The gene discussed is IL13; the disease is Alzheimer disease.