CFTR and cystic fibrosis: Overall, our findings indicating that CF neutrophils have prolonged survival and activity due to dysfunctional apoptosis (44, 49) and reverse migration, providing an explanation as to how CFTR mutations may lead to unresolved neutrophilic responses, impaired tissue repair resulting in scar formation or fibrosis in CF lung, and highlighting various approaches that aim at modulating these mechanisms to limit inflammation-driven tissue damage and promote tissue repair.