CFTR and cystic fibrosis: Exploiting CFTR-depleted zebrafish larvae as an innovative vertebrate organism, we show here that (i) there is a direct role for CFTR in regulation of host innate immunity and tissue repair, (ii) the inflammatory pathology of CF is determined by alterations in neutrophil behavior, and finally, (iii) the pro-resolution molecule, Tanshinone IIA (TIIA), restores normal levels of inflammation and tissue repair in CF, with important implications for the treatment of CF.