Also, pulmonary macrophages secrete TNF-α stimulated gene-6 (TSG-6), which helps in the ALI resolution via promoting the M1 to M2 macrophage transition However, the efferocytosis of neutrophils by AMs during later stages of pneumonia helps in the resolution of lung inflammation due to expression of growth arrest-specific 6 (Gas6), a member of vitamin K-dependent family of proteins, which binds to its receptors Tyro3, Axl and Mer (TAM), or Mertk (148, 160). This evidence concerns the gene GAS6 and pneumonia.