Additionally, patients with ALI show an elevated chemokine (CXCL8 or IL-8, CXCL1, or keratinocyte-cell derived chemokine (KC), CXCL5, or epithelial cell-derived neutrophil-activating peptide-78 (ENA-78), and CCL-2) levels in their BALF, which further regulate neutrophil infiltration into the lungs (49, 50). The gene discussed is CXCL8; the disease is acute respiratory distress syndrome.