However, during streptococcal or pneumococcal pneumonia, AECs also express secreted and transmembrane (Sectm) 1, Sectm1a, and Sectm1b genes due to the type 1 IFN signaling induction in AECs via signal transducer and activator of transcription 1 (STAT-1) activation (103). Here, STAT1 is linked to pneumococcal pneumonia.