IL5 and acute respiratory distress syndrome: However, in another study, the ILC2s (as measured by the production of IL-5 and IL-13) pre-activation via intra-tracheal IL-33 administration before the lethal S. aureus sepsis protects the host from ALI and death via pulmonary eosinophilia induction, which clears the pathogen from the lungs and suppresses neutrophilia (221).