However, the uncontrolled inflammatory process causing severe ALI overpowers the resolution process, which causes irreversible damage during Gram-negative bacteria (Klebsiella pneumoniae)-induced sepsis as indicated by accumulation of the lungs with apoptosis-resistant neutrophils and elevation of pro-inflammatory cytokines (IL-1α, TNF-α) in BALF (12). The gene discussed is TNF; the disease is Sepsis.