Lipoxin A4 release by pulmonary endothelial cells, immigrated neutrophils, and pulmonary macrophages at later stages of pneumonia, inhibits neutrophil infiltration, promotes the efferocytosis of dead neutrophils by serving as a proapoptotic signal through downregulating Mac-1 (a β2 integrin) expression, to induce the pulmonary inflammation resolution (161–163). The gene discussed is ITGB2; the disease is pneumonia.