STAT6 and sarcoidosis: Other data from the model that point to a functional imbalance in favor of Th2-immune signaling in sarcoidosis was the relatively blunted INF-γ production associated with sarcoidosis following M.tb antigen stimulation and the significant inhibition of granuloma formation in sarcoidosis through pharmacologic signal transducer and activator of transcription 6 (STAT6) inhibition (45).