On the contrary, Ciecko et al. (38) reported that IL-27 contributes to the pathogenesis of T1D in NOD mice by altering the balance of Treg and TH1 cells and enhancing the effector function of CD8 T cells, although it was reported that serum IL-27 was strongly elevated in patients with SS (39), which is inconsistent with our results. This evidence concerns the gene CD8A and type 1 diabetes mellitus.