IGHE and allergic rhinitis: A DNA vaccine coexpressing Der p 2 and ubiquitin A20 encapsulated into nanoparticles used intranasally in a murine model of allergic rhinitis was able to inhibit allergen-specific IgE, IL-4, IL-10, and IL-17 secretion and to increase IgG1, IgG2a, and IFN-γ (86, 87).