GZMB and hepatocellular carcinoma: We extended this finding by demonstrating that intratumoral MAIT cells in HCC also exhibit higher expression of the effector genes GZMB and IFNG, even though studies of HCC and colorectal liver metastases have shown that MAIT cells isolated from tumor masses are suppressed in terms of TH1 cytokine secretion and granzyme B production when stimulated ex vivo (18, 20).