However, genes upregulated in patients with non-Salmonella acute infections showed enrichment for pathways typically associated with innate immune/inflammatory responses, while conversely the gene expression response in patients with iNTS could be explained by upregulation of genes that are associated with suppression of inflammation (NFKBIB, PI3K, REL, SIGIRR, SOCS4, SOCS7). The gene discussed is SIGIRR; the disease is intimal sarcoma.