Since Th17 lineage, driven by Retinoic acid receptor related orphan receptor gamma (RORC), represents another source of IL-22, we made efforts to investigate the expression of the transcription factor AHR, as well as RORC, in peripheral blood mononuclear cells (PBMCs) from patients with T2D and metabolically healthy obesity (MHO) subjects. Here, IL22 is linked to obesity due to melanocortin 4 receptor deficiency.