CTLA4 and neoplasm: The production of CXCL9 and CXCL10, predominantly by TAMs (CD11b+ Ly6Cint CD11c+ F4/80+), enhances CD8+ T cell infiltration and tumor control in response to combination anti-PD-1 and anti-CTLA-4 in a mouse model of mammary adenocarcinoma (30).