Although there is a strong correlation between elevated autoimmune AFC and GC responses, and significantly reduced frequency of B10 cells and their IL-10 production, currently we do not have the data to conclude whether loss of B10 cells upon TLR7 overexpression or overstimulation contribute to heightened AFC and GC responses in TLR7-driven SLE-autoimmunity. This evidence concerns the gene TLR7 and systemic lupus erythematosus.