HIF1A and lung carcinoma: Although, H2S has been shown to inhibit EMT in lung cancers through Wnt/Catenin signaling and the activation of HIF-1α (25, 33), HIF-1α is dramatically downregulated by gestational CS in the 7-days old mouse lung (11, 34) and, in some lung injuries, H2S promotes EMT and lung repair (35, 36).