We do not observe a rise in anti-tumor antibody detectable in the serum against B78 tumors after tumor re-challenge in mice cured of B78 by RT + IT-IC + anti-CTLA-4 after B cell depletion (Supplemental Figure 4), confirming a lack of antibody-based humoral memory response in B cell deficient mice. Here, CTLA4 is linked to neoplasm.