In mouse models of OVA-induced asthma, the intranasal IL-27 administration significantly improves the clinical symptoms of the disease, decreases the local eosinophilia in the nasal mucosa, modulates the cytokine production by Th1, Th2, and Treg cells, and decrease the serum levels of specific IgE (128, 129). Here, IGHE is linked to asthma.