However, inflammatory responses must eventually be terminated, otherwise, excessive and prolonged activation of NF-κB signaling will cause massive damage to the host and could lead to autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, and inflammatory bowel disease (3, 4). Here, NFKB1 is linked to rheumatoid arthritis.