Similarly, the exogenous AHR affinitive ligand, 10-chloro-7H-benzimidazo [2,1-a]benzo[de]isoquinolin-7-one (10-CI-BBQ), exhibits protection against T1D in NOD mice by inhibiting the formation of disease-associated CD4+ Nrp1+ Foxp3– RORγt+ cells. The gene discussed is AHR; the disease is type 1 diabetes mellitus.