IL25 and helminthiasis: Through examination of Pou2f3 null mice during a small intestinal helminth infection, Gerbe et al. (19) defined that IL-13 acted downstream of the tuft cell lineage, suggesting a tuft cell initiated IL-25-driven positive feed-forward loop resulting in ILC2 expansion and IL-13-driven tuft and goblet cell hyperplasia (Figure 1), essential for helminth expulsion (22, 23).