On the other hand, in an in-vitro model of RA, overexpression of hsa-miR-410-3p decreased the pro-inflammatory cytokines, TNF-α, IL-6, IL-1β, and MMP-9 (97) and was anti-proliferative and apoptotic in nature through targeting of transcription factor YY1 (98). This evidence concerns the gene YY1 and rheumatoid arthritis.