NFKB1 and osteoarthritis: For example, Zhang et al. revealed that YAP and TAZ acted as potent suppressors of TBK1, the central kinase in innate nucleic acid-sensing signaling (33); Deng et al. revealed that YAP/TAZ attenuated NF-κB signaling by directly inhibiting IKKα/β activation in an osteoarthritis murine model (88); Ni et al. found that YAP was highly expressed in Treg cells to amplify TGFβ-SMAD activation, which strengthened Foxp3 expression and Treg functions (87).