LATS1 and neoplasm: On the other hand, the Guan group reported that deletion of kinases LATS1/2, which resulted in YAP/TAZ activation, induced the secretion of nucleic acid-rich extracellular vesicles (EVs) to promote IFN-I production, dendritic cell maturation, and CD8+ T-cell expansion and eventually contributed to anti-tumor immunity (93).