YAP1 and hepatocellular carcinoma: For example, the activation of YAP in hepatocellular carcinoma underlies the M2 macrophage recruitment by tumor-initiating cells (TICs) (63) or promotes the migration and infiltration of M1-like macrophages (53), while the genetic deletion of Mst1/2 in hepatocytes upregulates MCP1 expression and causes a massive infiltration of macrophages with mixed M1 and M2 phenotypes, which promotes the development of HCC (64).