IL10 and atherosclerosis: Administration of IL-10 alleviated atherosclerosis in Ldlr−/− mice (128), whereas inhibition of IL-10 by a genetic approach or antibody blocking aggravated the disease (129, 130), which could be caused either directly by the atheroprotective role of IL-10 or indirectly by the enhanced Th1 differentiation and macrophages accumulation in atherosclerotic lesions in the absence of IL-10, or a combination of both (127, 129, 131).