Likewise, deficiency of T-bet in Ldlr−/− mice (94) also resulted in a 30% reduction of atherosclerosis, accompanied by a concurrent increase of Th2 cytokine (IL-4, IL-5, and IL-10) and immunoglobulin M (IgM) (an atheroprotective natural antibody up-regulated with IL-5) (95). This evidence concerns the gene IL10 and atherosclerosis.