With regard to the role of IL-18 in atherogenesis, less disease was found in ApoE−/− mice when a plasmid encoding a soluble, recombinant IL-18-binding protein was administrated to block bioavailable IL-18 (96), whereas direct injection of IL-18 recombinant protein accelerated atherosclerosis (102). The gene discussed is IL18; the disease is atherosclerosis.