A further mechanistic study demonstrated that CD8+T cells could mobilize the granulocyte and monocyte progenitors in the bone marrow and spleen via IFN-g to increase circulating Ly6C monocytes, which migrated into vascular tissues and differentiated into the proatherogenic macrophages (144), indicating alternative mechanisms of these cytotoxic T cells in regulating innate immune cell responses in atherosclerosis. Here, CD8A is linked to atherosclerosis.