Rimessi et al. have characterized the role of mitochondria as drivers of the P. aeruginosa-triggered inflammatory exacerbation in CF airway cells, demonstrating that mitochondrial Ca2+ signaling plays a critical role in inflammasome NLRP3 recruitment and inflammasome-dependent IL-1β and IL-18 release in CF airway cell lines and in CF patient-derived airway primary cells (132). Here, IL18 is linked to cystic fibrosis.