β-sitosterol (BSS) was used to inhibit the active form of PKCs involved in the transduction of P. aeruginosa-dependent pro-inflammatory Ca2+-dependent signaling in CF patient-derived airway epithelial cells, leading to a significant reduction in expression of IL-8, growth-related oncogene (GRO)-α, and GRO-β (170). The gene discussed is CXCL8; the disease is cystic fibrosis.