Ikarugamycin and quercetin have been identified as possible candidates for anti-inflammatory approaches, analyzing their effects on A20 and NF-κB(p65) expression (mRNA) as well as IL-8 pro-inflammatory cytokine release in the presence and absence of bacterial LPS in bronchial epithelial cells lines and in primary nasal epithelial cells from patients with CF and non-CF controls (215). Here, NFKB1 is linked to cystic fibrosis.