CFTR and cystic fibrosis: The oxidative stress in CF lung may: (I) affect autophagy, compromising the expression of CFTR channel (120, 121); (II) induce mtDNA oxidation and damage, triggering inflammasome activation, and/or altering the OXPHOS activity, that in turn produces additional ROS (122, 123); and (III) destroy lung tissue, affecting the cell function and/or exacerbating the inflammatory response (37).