NLRC4 and cystic fibrosis: CF airway cell lines and CF patient-derived airway primary cells are prone to P. aeruginosa-dependent mitochondrial perturbations, in which the mitochondrial Ca2+ uniporter (MCU) is a signal-integrating organelle that mediates mitochondrial ROS-dependent NLRP3 inflammasome activation and recruitment of both NLRP3 and NLRC4 inflammasome (132).