Its Ca2+ influx capacity is enhanced in F508delCFTR and G551D-CFTR cells (158, 159); (II) the Store Operated Ca2+ Entry (SOCE) resulted in significantly increased CF airway cell lines and primary cells, due to an enhanced Orai1 channel insertion to PM, with consequent exacerbation of IL-8 secretion (160); and (III) the TRP channel TRPA1, expressed in bronchial columnar epithelial cells. Here, CXCL8 is linked to cystic fibrosis.