C5AR1 and cystic fibrosis: Among the soluble mediators of inflammation detected in CF bronchoalveolar lavage fluid, the most potent chemokines recruiting neutrophils have attracted particular interest, both in terms of pathophysiology and therapeutic perspectives, namely the complement system-derived C5a, the leukotriene B4 (LTB4), and the chemokine Interleukin(IL)-8.