Recently, it has been observed that the CFTR corrector agent VX-809 and 4,6,4'-trimethylangelicin (TMA) treatment lead to partial restoration of the mitochondrial failure in CF airway cell lines, producing an improvement in complex-1 activity, Δψ generation, ANT-dependent ADP/ATP exchange, and membrane lipid peroxidation (137). Here, CFTR is linked to cystic fibrosis.