Ca2+ signaling dysregulations were observed in several human CF airway epithelial cell lines, where the intracellular Ca2+ concentration is increased compared to non-CF cells (150) due to: (I) intrinsic defects associated with CFTR deficiency, (II) chronic exposure to bacterial infection, and (III) persistent stimulation by pro-inflammatory mediators. This evidence concerns the gene CFTR and cystic fibrosis.