We therefore detected the expression of OAS2 in human primary keratinocytes (Figure 4B), and found that OAS2 was more actively expressed in primary psoriasis lesional epidermal keratinocyte (PLEK) than normal human epidermal keratinocyte (NHEK) and psoriasis non-lesional epidermal keratinocyte (NLEK), but rarely expressed in fibroblasts (Figures 4C,D). This evidence concerns the gene OAS2 and psoriasis.