Approaches that already implement combinatorial targeting of AML LSCs include tri-specific killer engagers against CD33 and CD123 (373), compound CAR T-cells against CD33 and CD123 (374) or CLL-1 and CD33 (i.e., NCT03795779), universal CAR T-cells against CD33 and CD123 (375), and CAR CIK-cells against CD33 and CD123 (376). This evidence concerns the gene CLEC12A and acute myeloid leukemia.