Moreover, although a Listeria monocytogenes lgt mutant fails to activate TLR2 signaling it is significantly less virulent in a mouse infection model (Machata et al., 2008), whereas lgt mutants of Streptococcus agalactiae (Henneke et al., 2008) and Staphylococcus aureus (Bubeck Wardenburg et al., 2006; Mohammad et al., 2019) are hypervirulent in mouse infection models. The gene discussed is TLR2; the disease is infection.