HSC70 has been reported to be associated with the cell entry step of DENV through interacting with envelope glycoprotein E. HSC70 is highly expressed on the surface of C6/36 cells infected with DENV via relocation, and incubating with antibodies to HSC70 significantly blocks DENV binding to the C6/36 surface and further inhibits virus infection (Vega-Almeida et al., 2013). This evidence concerns the gene HSPA8 and viral infectious disease.