PLOD1 and hypogonadotropic hypogonadism: The prevalence of anterior pituitary hormone deficiency was as follows: ACTH, 14/25 (56%); GH, 12/25 (48%); TSH, 9/25 (36%); and LH/FSH, 4/23 (17%; 4 patients with hypogonadotropic hypogonadism).