INS and type 2 diabetes mellitus: Genazzani and colleagues demonstrated that the combined administration of ALA and MI to obese PCOS women, grouped by the presence or absence of familiarity with type 1 or T2DM, led to an improvement of insulin sensitivity in patients with T2DM familiarity and an improvement in the insulin response to OGTT in both groups, unlike what was observed after treatment with MI alone (155).