ASO-mediated ANGPTL3 inhibition in mice with different lipid phenotypes (wildtype C57BL/6 mice, Ldlr−/− mice, Apoc3−/−Ldlr−/− mice, heterozygous Apoc3+/−Ldlr−/− mice, diet-induced obese mice, and mice over-expressing human APOC3) resulted in lowered plasma TGs, LDL-C and HDL-C and reduced atherosclerosis (50). The gene discussed is APOC3; the disease is atherosclerosis.