ENPP1 and Pseudoxanthoma elasticum: For example, ectopic mineralization was shown surrounding the eye, in the wall of the bulbus arteriosus of the heart and in the ventral skin of the dragon fish (dgf−/−), a knock-out zebrafish model for the gene that encodes Enpp1, and modeled for generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE) (105, 106).